In Resident Evil 5, the first time you encounter "lickers", they're being held in rooms with transparent walls. Sense tells us that these transparent walls should be strong enough to keep the lickers inside.
Nope. Guess what happens 10 seconds later.
You're waiting for an elevator in the next room, and the lickers break the glass and come after you.
While terrifying, looking back on this encounter makes me wonder "Why in the world would scientists keep dangerous monsters enclosed in glass they might be able to break?"
"Oh but they might of been in there without food and have become desperate" some may say. That would only make sense if -- as beasts -- they didn't eat eachother until there was only one left. If they had, blood (or entrails or whatever) would cover the walls, and only one monster would remain. It doesn't make any sense that a group of monsters would suddenly snap and break their container once food appears outside the container while they had plenty of "food" inside the container.
"Oh but they might of gotten strong enough to break the glass in the time the scientists were gone" others might say. Really? How exactly does a group of monsters get stronger AFTER they've spent a significant amount of time with no sources of nutrition? Adrenaline? The scientists are dealing with frikkin' monsters. They should of been well aware of how adrenaline affects them. The only logical reason I can think of at the moment for why they wouldn't act on that knowledge would be because of budget issues (after all, we are dealing with an evil organization that likely doesn't care about the well-being of their intellectual investments).
Scientists aren't idiots.
Oh, as for how this particular situation could of been remedied in the game's design, how about an internal stimulus such as one monster attacking another and the fight results in cracking (but not breaking) the glass, or an external stimulus such as a character getting shoved into the glass?